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Article

TMBleR: a bioinformatic tool to optimize TMB estimation and predictive power.

Bioinformatics (Oxford, England) - 4 Mar 2022

Fancello Laura, Guida Alessandro, Frige Gianmaria, Ceol Arnaud Gerard Michel, Babini Gabriele, Scaglione Giovanni Luca, Zanfardino Mario, Mazza Tommaso, Ferrando Lorenzo, Pelicci Pier Giuseppe, Mazzarella Luca

Abstract excerpt

MOTIVATION: Tumor mutational burden (TMB) has been proposed as a predictive biomarker for immunotherapy response in cancer patients, as it is thought to enrich for tumors with high neoantigen load. TMB assessed by whole-exome sequencing is considered the gold standard but remains confined to research settings. In the clinical setting, targeted gene panels sampling various genomic sizes along with diverse...

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PMID: 34927668
DOI: 10.1093/bioinformatics/btab836

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