Article
Multiple-ancestry genome-wide association study identifies 27 loci associated with measures of hemolysis following blood storage.
The Journal of clinical investigation - 1 Jul 2021
Page Grier P, Kanias Tamir, Guo Yuelong J, Lanteri Marion C, Zhang Xu, Mast Alan E, Cable Ritchard G, Spencer Bryan R, Kiss Joseph E, Fang Fang, Endres-Dighe Stacy M, Brambilla Donald, Nouraie Mehdi, Gordeuk Victor R, Kleinman Steve, Busch Michael P, Gladwin Mark T
Abstract excerpt
BackgroundThe evolutionary pressure of endemic malaria and other erythrocytic pathogens has shaped variation in genes encoding erythrocyte structural and functional proteins, influencing responses to hemolytic stress during transfusion and disease.MethodsWe sought to identify such genetic variants in blood donors by conducting a genome-wide association study (GWAS) of 12,353 volunteer donors, including 1,406...
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