Article
Methylcytosine dioxygenase TET3 interacts with thyroid hormone nuclear receptors and stabilizes their association to chromatin.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 2017
Guan Wenyue, Guyot Romain, Samarut Jacques, Flamant Frédéric, Wong Jiemin, Gauthier Karine Cécile
Abstract excerpt
Thyroid hormone receptors (TRs) are members of the nuclear hormone receptor superfamily that act as ligand-dependent transcription factors. Here we identified the ten-eleven translocation protein 3 (TET3) as a TR interacting protein increasing cell sensitivity to T3. The interaction between TET3 and TRs is independent of TET3 catalytic activity and specifically allows the stabilization of TRs on chromatin. We...
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