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Article

Thyroid hormone receptor mutations and disease: beyond thyroid hormone resistance.

Trends in endocrinology and metabolism: TEM - 1 Jan 2000

Cheng Sheue-yann

Abstract excerpt

Thyroid hormone receptors (TRs) are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Two THR genes (A and B), located on different chromosomes, yield four T3-binding isoforms with highly conserved sequences in the DNA- and ligand-binding domains. Mutations of THRB cause a human genetic disease, thyroid hormone resistance syndrome (RTH). Comprehensive genomic...

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Source

Identifiers

PMID: 15860414
DOI: 10.1016/j.tem.2005.03.008

Genes

THRA
THRB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Thyroid hormone receptor mutations and disease: beyond thyroid hormone resistance.PMID 15860414Read ↗

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Thyroid hormone resistance syndrome due to mutations in the thyroid hormone receptor α gene (THRA).Semantic proximity Read ↗

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Mechanisms by which thyroid hormone receptor mutations cause clinical syndromes of resistance to thyroid hormone.Semantic proximity Read ↗

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