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Article

Quantitative MODS-Wayne assay for rapid detection of pyrazinamide resistance in Mycobacterium tuberculosis from sputum samples.

Microbiology spectrum - 5 Dec 2024

Toscano-Guerra Emily, Alcántara Roberto, Untiveros Katherine Lozano, Gilman Robert, Grandjean Louis, Zimic Mirko, Sheen Patricia

Abstract excerpt

Tuberculosis (TB) remains a significant global health challenge, exacerbated by the emergence of drug-resistant strains, such as those resistant to pyrazinamide (PZA). The current scarcity of affordable and precise quantitative diagnostic tests for PZA resistance underscores the urgent need for more accessible diagnostic tools. We evaluated PZA susceptibility in 264 TB-positive samples by quantifying pyrazinoic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39540764
DOI: 10.1128/spectrum.00471-24
PMCID: PMC11619452

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