Article
Rapid colorimetric testing for pyrazinamide susceptibility of M. tuberculosis by a PCR-based in-vitro synthesized pyrazinamidase method.
PloS one - 1 Jan 2011
Zhou Man, Geng Xuelei, Chen Jun, Wang Xude, Wang Dianbing, Deng Jiaoyu, Zhang Zhiping, Wang Weihua, Zhang Xian-En, Wei Hongping
Abstract excerpt
Pyrazinamide (PZA) is an important first-line anti-tuberculosis drug. But PZA susceptibility test is challenging because PZA activity is optimal only in an acid environment that inhibits the growth of M. tuberculosis. For current phenotypic methods, inconsistent results between different labs have been reported. Direct sequencing of pncA gene is being considered as an accurate predictor for PZA susceptibility,...
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