Article
Genotypic Resistance of Pyrazinamide but Not Minimum Inhibitory Concentration Is Associated With Longer Time to Sputum Culture Conversion in Patients With Multidrug-resistant Tuberculosis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 2 Nov 2021
Kuhlin Johanna, Davies Forsman Lina, Mansjö Mikael, Jonsson Nordvall Michaela, Wijkander Maria, Wagrell Charlotta, Jonsson Jerker, Groenheit Ramona, Werngren Jim, Schön Thomas, Bruchfeld Judith
Abstract excerpt
BACKGROUND: Pyrazinamide (PZA) resistance in multidrug-resistant tuberculosis (MDR-TB) is common; yet, it is not clear how it affects interim and treatment outcomes. Although rarely performed, phenotypic drug susceptibility testing (pDST) is used to define PZA resistance, but genotypic DST (gDST) and minimum inhibitory concentration (MIC) could be beneficial. We aimed to assess the impact of PZA gDST and MIC on...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.