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Article

A simplified pyrazinamidase test for Mycobacterium tuberculosis pyrazinamide antimicrobial susceptibility testing.

Journal of clinical microbiology - 11 Dec 2024

Chan Hsin-Hua, Wang Yu-Chen, Jou Ruwen

Abstract excerpt

Pyrazinamide (PZA) is an important first-line drug for tuberculosis (TB) treatment by eradicating the persisting Mycobacterium tuberculosis complex (MTBC). Due to cost and technical challenges, end TB strategies are hampered by the lack of a simple and reliable culture-based PZA antimicrobial susceptibility testing (AST) for routine use. We initially developed a simplified chromogenic pyrazinamidase (PZase) test...

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Identifiers

PMID: 39555932
DOI: 10.1128/jcm.01227-24
PMCID: PMC11633146

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