Article
Colorimetric methods for rapid determination of pyrazinamide resistance.
International journal of mycobacteriology - 1 Jan 2000
Akbal Ahmet Ugur, Durupinar Belma, Coban Ahmet Yilmaz
Abstract excerpt
Background: Because pyrazinamide (PZA) is only effective for Mycobacterium tuberculosis at an acidic pH, susceptibility tests are more difficult to perform than those for other anti-tuberculosis (TB) drugs. The purpose of our work was to investigate the effectiveness of colorimetric methods to detect PZA susceptibility and to detect pncA gene mutations in resistant isolates by sequence analysis. Methods: In this...
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