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Article

Low-frequency variants in genes involved in glutamic acid metabolism and γ-glutamyl cycle and risk of coronary artery disease in type 2 diabetes.

Cardiovascular diabetology - 13 Nov 2024

Giuffrida Fernando M A, Rai Sharan K, Tang Yaling, Mendonça Christine, Frodsham Scott G, Shah Hetal S, Pezzolesi Marcus G, Sun Qi, Doria Alessandro

Abstract excerpt

BACKGROUND: A common genetic variant at the glutamate-ammonia ligase (GLUL) locus has been previously associated with an increased risk of coronary artery disease (CAD) as well as alterations of glutamic acid metabolism and the γ-glutamyl cycle in individuals with type 2 diabetes (T2D). Here we investigated whether less frequent variants in GLUL and 15 additional genes in these pathways are associated with...

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Source

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Identifiers

PMID: 39538235
DOI: 10.1186/s12933-024-02442-5
PMCID: PMC11562816

Genes

CAD
MAF
GLUL
DPEP2
GGCT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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