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Article

Polymorphism in the 5'-flanking region of human glutamate-cysteine ligase modifier subunit gene is associated with myocardial infarction.

Circulation - 25 Jun 2002

Nakamura Shin-ichi, Kugiyama Kiyotaka, Sugiyama Seigo, Miyamoto Shinji, Koide Shun-ichi, Fukushima Hironobu, Honda Osamu, Yoshimura Michihiro, Ogawa Hisao

Abstract excerpt

BACKGROUND: Human glutamate-cysteine ligase (GCL) is a rate-limiting enzyme for the synthesis of glutathione that plays a crucial role in antioxidant defense mechanisms in most mammalian cells, including vascular cells. Oxidants transcriptionally upregulate GCL genes for glutathione synthesis, providing a protective mechanism against oxidative stress-induced cellular dysfunction. This study examined the...

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Source

Identifiers

PMID: 12081989
DOI: 10.1161/01.cir.0000019739.66514.1e

Genes

GCLM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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