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Article

In Silico Preliminary Association of Ammonia Metabolism Genes GLS, CPS1, and GLUL with Risk of Alzheimer's Disease, Major Depressive Disorder, and Type 2 Diabetes.

Journal of molecular neuroscience : MN - 1 Mar 2018

Griffin Jeddidiah W D, Liu Ying, Bradshaw Patrick C, Wang Kesheng

Abstract excerpt

Ammonia is a toxic by-product of protein catabolism and is involved in changes in glutamate metabolism. Therefore, ammonia metabolism genes may link a range of diseases involving glutamate signaling such as Alzheimer's disease (AD), major depressive disorder (MDD), and type 2 diabetes (T2D). We analyzed data from a National Institute on Aging study with a family-based design to determine if 45 single nucleotide...

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Source

Identifiers

PMID: 29441491
DOI: 10.1007/s12031-018-1035-0

Genes

GLS
CPS1
GLUL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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