Article
Genetic variants in glutamate cysteine ligase confer protection against type 2 diabetes.
Molecular biology reports - 1 Aug 2020
Azarova Iuliia, Klyosova Elena, Lazarenko Victor, Konoplya Alexander, Polonikov Alexey
Abstract excerpt
Oxidative stress contributes to the pathogenesis of type 2 diabetes (T2D). This study investigated whether single nucleotide polymorphisms (SNPs) at genes encoding glutamate cysteine ligase catalytic (rs12524494, rs17883901, rs606548, rs636933, rs648595, rs761142 at GCLC) and modifier (, , , at GCLM) subunits are associated with susceptibility to type 2 diabetes. 2096...
