Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes.

doi:10.1001/jama.2013.276305

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes.

JAMA - 28 Aug 2013

Qi Lu, Qi Qibin, Prudente Sabrina, Mendonca Christine, Andreozzi Francesco, di Pietro Natalia, Sturma Mariella, Novelli Valeria, Mannino Gaia Chiara, Formoso Gloria, Gervino Ernest V, Hauser Thomas H, Muehlschlegel Jochen D, Niewczas Monika A, Krolewski Andrzej S, Biolo Gianni, Pandolfi Assunta, Rimm Eric, Sesti Giorgio, Trischitta Vincenzo, Hu Frank, Doria Alessandro

Abstract excerpt

IMPORTANCE: Diabetes is associated with an elevated risk of coronary heart disease (CHD). Previous studies have suggested that the genetic factors predisposing to excess cardiovascular risk may be different in diabetic and nondiabetic individuals. OBJECTIVE: To identify genetic determinants of CHD that are specific to patients with diabetes. DESIGN, SETTING, AND PARTICIPANTS: We studied 5 independent sets of CHD...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Coronary Disease

Share to Diabetes Mellitus, Type 2

Share to Glutamate-Ammonia Ligase

Share to Glutamic Acid

Share to Glutamine

Share to Risk

Share to United States

Source

Open in PubMed Open full text

Identifiers

PMID: 23982368
DOI: 10.1001/jama.2013.276305
PMCID: PMC3858847

Genes

GLUL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes.PMID 23982368Read ↗

Low-frequency variants in genes involved in glutamic acid metabolism and γ-glutamyl cycle and risk of coronary artery disease in type 2 diabetes.Semantic proximity Read ↗

Genetic Variant at the GLUL Locus Predicts All-Cause Mortality in Patients With Type 2 Diabetes.Semantic proximity Read ↗

Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids.Semantic proximity Read ↗

The SNP rs10911021 is associated with oxidative stress in coronary heart disease patients from Pakistan.Semantic proximity Read ↗

Genetic susceptibility to coronary heart disease in type 2 diabetes: 3 independent studies.Semantic proximity Read ↗

Polymorphism rs564398 of the ANRIL Gene as a Coronary-Artery-Disease-Associated SNP in Diabetic Patients of the Kazakh PopulationSemantic proximity Read ↗

In Silico Preliminary Association of Ammonia Metabolism Genes GLS, CPS1, and GLUL with Risk of Alzheimer's Disease, Major Depressive Disorder, and Type 2 Diabetes.Semantic proximity Read ↗

Genetic variants in glutamate cysteine ligase confer protection against type 2 diabetes.Semantic proximity Read ↗

Nonfasting glucose, ischemic heart disease, and myocardial infarction: a Mendelian randomization study.Semantic proximity Read ↗

Association of lipoprotein lipase D9N polymorphism with myocardial infarction in type 2 diabetes: the genetics, outcomes, and lipids in type 2 diabetes (GOLD) study.Semantic proximity Read ↗

Genetically Low Antioxidant Protection and Risk of Cardiovascular Disease and Heart Failure in Diabetic Subjects.Semantic proximity Read ↗

Mitochondrial gene expression in diabetes mellitus: effect of nutrition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.