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Antagonism between Front-Line Antibiotics Clarithromycin and Amikacin in the Treatment of Mycobacterium abscessus Infections Is Mediated by the whiB7 Gene

5 Sept 2017

Abstract excerpt

ABSTRACT Combinations of antibiotics, each individually effective against Mycobacterium abscessus , are routinely coadministered based on the concept that this minimizes the spread of antibiotic resistance. However, our in vitro data contradict this assumption and instead document antagonistic interactions between two antibiotics (clarithromycin and amikacin) used to treat M. abscessus infections. Clinically...

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PMID: 28874379
DOI: 10.1128/aac.01353-17

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