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Article

A stop-gain mutation in sigma factor SigH (MAB_3543c) may be associated with tigecycline resistance in Mycobacteroides abscessus.

Journal of medical microbiology - 1 Jul 2021

Lee Col Lin, Ng Hien Fuh, Ngeow Yun Fong, Thaw Zin

Abstract excerpt

Introduction. Tigecycline is currently acknowledged to be one of the most effective antibiotics against infections caused by Mycobacteroides abscessus.Gap statement. The genetic determinants of tigecycline resistance in M. abscessus are not well understood.Aim. In this study, we characterized a tigecycline-resistant M. abscessus mutant, designated CL7, to identify the potential resistance mechanism.Methodology....

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Identifiers

PMID: 34236301
DOI: 10.1099/jmm.0.001378

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