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TET2 regulates early and late transitions in exhausted CD8 + T cell differentiation and limits CAR T cell function

13 Nov 2024

Abstract excerpt

CD8 + T cell exhaustion hampers control of cancer and chronic infections and limits chimeric antigen receptor (CAR) T cell efficacy. Targeting TET2 in CAR T cells provides therapeutic benefit; however, TET2’s role in exhausted T cell (T EX ) development is unclear. In chronic lymphocytic choriomeningitis virus (LCMV) infection, TET2 drove conversion from stem cell–like T EX progenitors toward terminally...

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PMID: 39536093
DOI: 10.1126/sciadv.adp9371

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