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Article

Long-Term Persistence of Exhausted CD8 T Cells in Chronic Infection Is Regulated by MicroRNA-155.

Cell reports - 15 May 2018

Stelekati Erietta, Chen Zeyu, Manne Sasikanth, Kurachi Makoto, Ali Mohammed-Alkhatim, Lewy Keith, Cai Zhangying, Nzingha Kito, McLane Laura M, Hope Jennifer L, Fike Adam J, Katsikis Peter D, Wherry E John

Abstract excerpt

Persistent viral infections and tumors drive development of exhausted T (TEX) cells. In these settings, TEX cells establish an important host-pathogen or host-tumor stalemate. However, TEX cells erode over time, leading to loss of pathogen or cancer containment. We identified microRNA (miR)-155 as a key regulator of sustained TEX cell responses during chronic lymphocytic choriomeningitis virus (LCMV) infection....

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Identifiers

PMID: 29768211
DOI: 10.1016/j.celrep.2018.04.038
PMCID: PMC5986283

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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