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Selective control of transposable element expression during T cell exhaustion and anti–PD-1 treatment

27 Oct 2023

Abstract excerpt

In chronic infections and cancer, T cells are exposed to prolonged antigen stimulation, resulting in loss of function (or exhaustion) and impairment of effective immunological protection. Exhausted T cells are heterogeneous and include early progenitors (Tpex) and terminally exhausted cells (Tex). Here, we used bulk and single-cell transcriptomics to analyze expression of transposable elements (TEs) in...

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PMID: 37889984
DOI: 10.1126/sciimmunol.adf8838

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