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Article

Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance

13 May 2021

Abstract excerpt

T cells triggers exhaustion, a distinct differentiation state with diminished effector function. Exhausted cells exist in multiple differentiation states, from stem-like progenitors that are the key mediators of the response to checkpoint blockade, through to terminally exhausted cells. Due to its clinical relevance, there is substantial interest in defining the pathways that control differentiation and...

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PMID: 33986293
DOI: 10.1038/s41467-021-23044-9

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