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Diversity of Transcriptional Regulatory Adaptation in E. coli.

Molecular biology and evolution - 1 Nov 2024

Dalldorf Christopher, Hefner Ying, Szubin Richard, Johnsen Josefin, Mohamed Elsayed, Li Gaoyuan, Krishnan Jayanth, Feist Adam M, Palsson Bernhard O, Zielinski Daniel C

Abstract excerpt

The transcriptional regulatory network (TRN) in bacteria is thought to rapidly evolve in response to selection pressures, modulating transcription factor (TF) activities and interactions. In order to probe the limits and mechanisms surrounding the short-term adaptability of the TRN, we generated, evolved, and characterized knockout (KO) strains in Escherichia coli for 11 regulators selected based on measured...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39531644
DOI: 10.1093/molbev/msae240
PMCID: PMC11588850

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TF

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