Article
Laboratory Evolution Reveals Transcriptional Mechanisms Underlying Thermal Adaptation of Escherichia coli.
Genome biology and evolution - 30 Sept 2025
Rychel Kevin, Chen Ke, Catoiu Edward A, Olson Elina, Sandberg Troy E, Gao Ye, Xu Sibei, Hefner Ying, Szubin Richard, Patel Arjun, Feist Adam M, Palsson Bernhard O
Abstract excerpt
Adaptive laboratory evolution is able to generate microbial strains, which exhibit extreme phenotypes, revealing fundamental biological adaptation mechanisms. Here, we use adaptive laboratory evolution to evolve Escherichia coli strains that grow at temperatures as high as 45.3 °C, a temperature lethal to wild-type cells. The strains adopted a hypermutator phenotype and employed multiple systems-level adaptations...
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