Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Global pleiotropic effects in adaptively evolved Escherichia coli lacking CRP reveal molecular mechanisms that define the growth physiology.

Open biology - 1 Feb 2022

Pal Ankita, Iyer Mahesh S, Srinivasan Sumana, Narain Seshasayee Aswin Sai, Venkatesh K V

Abstract excerpt

Evolution facilitates emergence of fitter phenotypes by efficient allocation of cellular resources in conjunction with beneficial mutations. However, system-wide pleiotropic effects that redress the perturbations to the apex node of the transcriptional regulatory networks remain unclear. Here, we elucidate that absence of global transcriptional regulator CRP in Escherichia coli results in alterations in key...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Evolution
Share to Cyclic AMP Receptor Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Energy Metabolism

Share to Escherichia coli

Share to Escherichia coli Proteins

Share to Gene Expression Regulation, Bacterial

Share to Metabolic Networks and Pathways

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 35167766
DOI: 10.1098/rsob.210206
PMCID: PMC8846999

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Global pleiotropic effects in adaptively evolved Escherichia coli lacking CRP reveal molecular mechanisms that define the growth physiology.PMID 35167766Read ↗

Omic data from evolved E. coli are consistent with computed optimal growth from genome-scale models.Semantic proximity Read ↗

The hallmarks of a tradeoff in transcriptomes that balances stress and growth functions.Semantic proximity Read ↗

Global Rebalancing of Cellular Resources by Pleiotropic Point Mutations Illustrates a Multi-scale Mechanism of Adaptive Evolution.Semantic proximity Read ↗

Reconstructing organisms in silico: genome-scale models and their emerging applications.Semantic proximity Read ↗

The E. coli molecular phenotype under different growth conditions.Semantic proximity Read ↗

Multi-omics Quantification of Species Variation of Escherichia coli Links Molecular Features with Strain Phenotypes.Semantic proximity Read ↗

Experimental Evolution Reveals Unifying Systems-Level Adaptations but Diversity in Driving Genotypes.Semantic proximity Read ↗

Catabolic regulation analysis of Escherichia coli and its crp, mlc, mgsA, pgi and ptsG mutants.Semantic proximity Read ↗

Synergistic interactions between glycogen and trehalose mediate adaptation to the stationary phase in E. coli.Semantic proximity Read ↗

Diversity of Transcriptional Regulatory Adaptation in E. coli.Semantic proximity Read ↗

Metabolic footprint analysis of recombinant Escherichia coli strains during fed-batch fermentations.Semantic proximity Read ↗

Interactions between genotype and environment drive the metabolic phenotype within Escherichia coli isolates.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.