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Article

Experimental evolution of diverse Escherichia coli metabolic mutants identifies genetic loci for convergent adaptation of growth rate.

PLoS genetics - 1 Mar 2018

Wytock Thomas P, Fiebig Aretha, Willett Jonathan W, Herrou Julien, Fergin Aleksandra, Motter Adilson E, Crosson Sean

Abstract excerpt

Cell growth is determined by substrate availability and the cell's metabolic capacity to assimilate substrates into building blocks. Metabolic genes that determine growth rate may interact synergistically or antagonistically, and can accelerate or slow growth, depending on genetic background and environmental conditions. We evolved a diverse set of Escherichia coli single-gene deletion mutants with a spectrum of...

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PMID: 29584733
DOI: 10.1371/journal.pgen.1007284
PMCID: PMC5892946

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Source receipt: pubmed, retrieved 7 Sept 2026.

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