Serum soluble isoform of receptor for advanced glycation end product is a predictive biomarker for acute exacerbation of idiopathic pulmonary fibrosis: a German and Japanese cohort study.

doi:10.1186/s12931-024-03014-7

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Article

Serum soluble isoform of receptor for advanced glycation end product is a predictive biomarker for acute exacerbation of idiopathic pulmonary fibrosis: a German and Japanese cohort study.

Respiratory research - 11 Nov 2024

Kitadai Erika, Yamaguchi Kakuhiro, Ohshimo Shinichiro, Iwamoto Hiroshi, Sakamoto Shinjiro, Horimasu Yasushi, Masuda Takeshi, Nakashima Taku, Hamada Hironobu, Bonella Francesco, Guzman Josune, Costabel Ulrich, Hattori Noboru

Abstract excerpt

BACKGROUND: The receptor for advanced glycation end product (RAGE) is a transmembrane receptor accelerating a pro-inflammatory signal. RAGE signalling is promoted by decreased soluble isoform of RAGE (sRAGE), which is a decoy receptor for RAGE ligands, and RAGE SNP rs2070600 minor allele. In Caucasian and Japanese cohorts, low circulatory sRAGE levels and presence of the minor allele are associated with poor...

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PMID: 39529063
DOI: 10.1186/s12931-024-03014-7
PMCID: PMC11552171

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