Article
Genetic variants in the receptor for advanced glycation end products (RAGE) gene were associated with circulating soluble RAGE level but not with renal function among Asians with type 2 diabetes: a genome-wide association study.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Oct 2017
Lim Su Chi, Dorajoo Rajkumar, Zhang Xiao, Wang Ling, Ang Su Fen, Tan Clara Si Hua, Yeoh Lee Ying, Ng Xiao Wei, Li Na, Su Chang, Liu Sylvia, Wong Melvin D S, Low Kiat Mun Serena, Yao Amy Ou, Babitha Jeevith, Fun Sharon, Zhou Shiyi, Lee Simon Biing Ming, Tang Wern Ee, Tavintharan Subramaniam, Sum Chee Fang, Liu Jian-Jun
Abstract excerpt
BACKGROUND: The soluble receptor for advanced glycation end products (sRAGE) has been shown to play an important role in diabetic complications. We conducted genome-wide association study (GWAS) of sRAGE in Asian type 2 diabetes mellitus (T2DM) patient and validated the association in an independent cohort of T2DM. METHODS: GWAS for sRAGE was performed in 2058 T2DM patients. Associations between single-nucleotide...
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