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Article

The Gly82Ser mutation in AGER contributes to pathogenesis of pulmonary fibrosis in combined pulmonary fibrosis and emphysema (CPFE) in Japanese patients.

Scientific reports - 30 Jul 2020

Kinjo Takumi, Kitaguchi Yoshiaki, Droma Yunden, Yasuo Masanori, Wada Yosuke, Ueno Fumika, Ota Masao, Hanaoka Masayuki

Abstract excerpt

The dominant pathogenesis underlying the combined pulmonary fibrosis and emphysema (CPFE) remains unresolved. The receptor for advanced glycation end-products (RAGE) is highly expressed in lung tissues and interacts with distinct multiple ligands, implicating it in certain lung diseases. To elucidate the pathogenesis of CPFE, we genotyped three single nucleotide polymorphisms (SNPs: rs2070600, rs1800625, and...

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Identifiers

PMID: 32732977
DOI: 10.1038/s41598-020-69184-8
PMCID: PMC7393115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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