Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-Wide CRISPR Screen Identifies Genes Involved in Metastasis of Pancreatic Ductal Adenocarcinoma

31 Oct 2024

Abstract excerpt

Background/Objectives: Early and aggressive metastasis is a major feature of pancreatic ductal adenocarcinoma. Understanding the processes underlying metastasis is crucial for making a difference to disease outcome. Towards these ends, we looked in a comprehensive manner for genes that are metastasis-specific. Methods: A genome-wide CRISPR-Cas9 gene knockout screen with 259,900 single guide RNA constructs was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to CAR-T cell therapy research
Share to CRISPR and Genetic Engineering

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39518122
DOI: 10.3390/cancers16213684

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-Wide CRISPR Screen Identifies Genes Involved in Metastasis of Pancreatic Ductal AdenocarcinomaPMID 39518122Read ↗

A Cancer Cell Cluster Marked by LincRNA MEG3 Leads Pancreatic Ductal Adenocarcinoma MetastasisSemantic proximity Read ↗

Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug targetSemantic proximity Read ↗

Exome sequencing and digital PCR analyses reveal novel mutated genes related to the metastasis of pancreatic ductal adenocarcinoma.Semantic proximity Read ↗

Identifying a gene signature of metastatic potential by linking pre-metastatic state to ultimate metastatic fateSemantic proximity Read ↗

BLIMP1 Induces Transient Metastatic Heterogeneity in Pancreatic CancerSemantic proximity Read ↗

CRISPR activation screening in a mouse model for drivers of hepatocellular carcinoma growth and metastasisSemantic proximity Read ↗

Advances in understanding the molecular mechanism of pancreatic cancer metastasis.Semantic proximity Read ↗

Hypoxia-induced metastatic heterogeneity in pancreatic cancerSemantic proximity Read ↗

Insertional mutagenesis defines drivers and evolutionary relationships in pancreatic cancer metastasisSemantic proximity Read ↗

Hypoxia-induced metastatic heterogeneity in pancreatic cancerSemantic proximity Read ↗

Transcriptomic and CRISPR/Cas9 technologies reveal FOXA2 as a tumor suppressor gene in pancreatic cancerSemantic proximity Read ↗

Integrated genomic and transcriptomic analysis reveals unique characteristics of hepatic metastases and pro-metastatic role of complement C1q in pancreatic ductal adenocarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.