Article

Identifying a gene signature of metastatic potential by linking pre-metastatic state to ultimate metastatic fate

2024-08-17

Abstract excerpt

Identifying the key molecular pathways that enable metastasis by analyzing the eventual metastatic tumor is challenging because the state of the founder subclone likely changes following metastatic colonization. To address this challenge, we labeled primary mouse pancreatic ductal adenocarcinoma (PDAC) subclones with DNA barcodes to characterize their pre-metastatic state using ATAC-seq and RNA-seq and determine t...

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Literature Corpus work: 2ec4d179-749d-526d-93c7-d5092a7e36aa
DOI: 10.1101/2024.08.14.607813

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