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Article

Exome sequencing and digital PCR analyses reveal novel mutated genes related to the metastasis of pancreatic ductal adenocarcinoma.

Cancer biology & therapy - 1 Aug 2012

Zhou Bin, Irwanto Astrid, Guo Yun-Miao, Bei Jin-Xin, Wu Qiao, Chen Ge, Zhang Tai-Ping, Lei Jin-Jv, Feng Qi-Sheng, Chen Li-Zhen, Liu Jianjun, Zhao Yu-Pei

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant cancers with more than 94% mortality rate mainly due to the widespread metastases. To find out the somatically mutated genes related to the metastasis of PDAC, we analyzed the matched tumor and normal tissue samples from a patient diagnosed with liver metastatic PDAC using intensive exome capture-sequencing analysis (> 170× coverage). Searching...

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Share to Carcinoma, Pancreatic Ductal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22797009
DOI: 10.4161/cbt.20839

Genes

KRAS
ADRB1
DCLK1
KCNH2
NOP14
SIGLEC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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