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Article

BLIMP1 Induces Transient Metastatic Heterogeneity in Pancreatic Cancer

8 Aug 2017

Abstract excerpt

Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most metastatic and deadly cancers. Despite the clinical significance of metastatic spread, our understanding of molecular mechanisms that drive PDAC metastatic ability remains limited. By generating a genetically engineered mouse model of human PDAC, we uncover a transient subpopulation of cancer cells with exceptionally high metastatic ability....

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PMID: 28790031
DOI: 10.1158/2159-8290.cd-17-0250

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