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Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target

3 Jul 2020

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) lethality is due to metastatic dissemination. Characterization of rare, heterogeneous circulating tumor cells (CTCs) can provide insight into metastasis and guide development of novel therapies. Using the CTC-iChip to purify CTCs from PDAC patients for RNA-seq characterization, we identify three major correlated gene sets, with stemness genes LIN28B/KLF4, WNT5A, and LGALS3...

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PMID: 32620742
DOI: 10.1038/s41467-020-17150-3

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