Article
Hypoxia-induced metastatic heterogeneity in pancreatic cancer
2025-08-29
Abstract excerpt
In most solid tumors, hypoxia constitutes a defining microenvironmental feature that reprograms malignant cells into a highly metastatic state by driving cellular plasticity and exacerbating chromosomal instability (CIN). However, the mechanisms by which cancer cells concurrently co-opt these elements of hypoxic adaptation to promote metastasis remains poorly understood. Here, we report that hypoxia promotes metas...
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Identifiers and source
- Literature Corpus work
- 06962fef-8cae-5d23-aace-4a1aa55fa86a
- DOI
- 10.1101/2025.08.26.672389