Article
m6A Modification of Profilin-1 in Vascular Smooth Muscle Cells Drives Phenotype Switching and Neointimal Hyperplasia via Activation of the p-ANXA2/STAT3 Pathway.
Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2024
Gao Xiao-Fei, Chen Ai-Qun, Tang Hao-Yue, Kong Xiang-Quan, Zhang Huan, Wang Zhi-Mei, Lu Wei, Wang Li-Guo, Wang Feng, Zhou Wen-Ying, Gu Yue, Zuo Guang-Feng, Ge Zhen, Zhang Jun-Jie, Chen Shao-Liang
Abstract excerpt
BACKGROUND: In-stent restenosis is characterized by a significant reduction in lumen diameter within the stented segment, primarily attributed to excessive proliferation of vascular smooth muscle cells (VSMCs) and neointimal hyperplasia. PFN1 (profilin-1), an actin-sequestering protein extensively studied in amyotrophic lateral sclerosis, remains less explored in neointimal hyperplasia. METHODS: Utilizing...
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