Article
Methyltransferase-like 3 suppresses phenotypic switching of vascular smooth muscle cells by activating autophagosome formation.
Cell proliferation - 1 Apr 2023
Fang Ze-Min, Zhang Shu-Min, Luo Hanshen, Jiang Ding-Sheng, Huo Bo, Zhong Xiaoxuan, Feng Xin, Cheng Wenlin, Chen Yue, Feng Gaoke, Wu Xingliang, Zhao Fang, Yi Xin
Abstract excerpt
Prevention of neointima formation is the key to improving long-term outcomes after stenting or coronary artery bypass grafting. RNA N6 -methyladenosine (m6 A) methylation has been reported to be involved in the development of various cardiovascular diseases, but whether it has a regulatory effect on neointima formation is unknown. Herein, we revealed that methyltransferase-like 3 (METTL3), the major...
Topics
- Humans
- Autophagosomes
- Cell Movement
- Cell Proliferation
- Cells, Cultured
- Matrix Metalloproteinase 2
- Methyltransferases
- Muscle, Smooth, Vascular
- Myocytes, Smooth Muscle
- Neointima
- Phenotype
- RNA