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Genetic Architecture of Addiction-Relevant Behaviors in Outbred Sprague-Dawley Rats Reveals Loci for Anxiety-Like and Nociceptive Traits.

Genes, brain, and behavior - 1 Jun 2026

Chitre Apurva S, Hebda-Bauer Elaine K, Emery Michael A, Li Fei, Nguyen Khai-Minh, Wang Yizhi, Cheng Riyan, Polesskaya Oksana, Watson Stanley J, Li Jun, Akil Huda, Palmer Abraham A

Abstract excerpt

Studies have shown that substance use liability is associated with novelty seeking, anxiety-like behavior, and pain sensitivity. We examined whether common genetic variation in outbred Sprague-Dawley rats explained variation in behavioral measures from three assays with established links to substance use: locomotor response to a novel environment, elevated plus maze, and tail flick. We estimated single-nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42145201
DOI: 10.1111/gbb.70053
PMCID: PMC13181434

Genes

F2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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