Article

CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake

2019-03-09

Abstract excerpt

Excessive alcohol intake is associated with 5.9% of global deaths. However, this figure is especially acute in men such that 7.6% of deaths can be attributed to alcohol intake. Previous studies identified a significant interaction between genotypes of the galanin ( GAL) gene with anxiety and alcohol abuse in different male populations but were unable to define a mechanism. To address these issues the current stud...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 935c5557-5be4-5eae-aebd-cfd2c29cb74f
DOI: 10.1101/572065

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intakeDOI 10.1101/572065Read

Differential activity by polymorphic variants of a remote enhancer that supports galanin expression in the hypothalamus and amygdala: implications for obesity, depression and alcoholism.Semantic proximity Read

Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117).Semantic proximity Read

Distinct Chrna5 mutations link excessive alcohol use to types I/II vulnerability profiles and IPN GABAergic neurons.Semantic proximity Read

Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112,117)Semantic proximity Read

Global deletion of <i>Malat1</i> alters alcohol consumption in a sex-specific mannerSemantic proximity Read

A genome-wide gene-by-trauma interaction study of alcohol misuse in two independent cohorts identifies PRKG1 as a risk locus.Semantic proximity Read

Molecular Alterations Caused by Alcohol Consumption in the UK Biobank: A Mendelian Randomisation Study.Semantic proximity Read

Impact of Fkbp5 × early life adversity × sex in humanised mice on multidimensional stress responses and circadian rhythmicity.Semantic proximity Read

Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)Semantic proximity Read

5. Collaborative Study on the Genetics of Alcoholism: Functional genomics.Semantic proximity Read

Interaction of genetic variation at ADH1B and MLXIPL with alcohol consumption for elevated serum urate level and gout among people of European ethnicity.Semantic proximity Read

Association between anxiety and non-coding genetic variants of the galanin neuropeptide.Semantic proximity Read