Article
CaClust: linking genotype to transcriptional heterogeneity of follicular lymphoma using BCR and exomic variants.
Genome biology - 5 Nov 2024
Oksza-Orzechowski Kazimierz, Quinten Edwin, Shafighi Shadi, Kiełbasa Szymon M, van Kessel Hugo W, de Groen Ruben A L, Vermaat Joost S P, Sepúlveda Yáñez Julieta H, Navarrete Marcelo A, Veelken Hendrik, van Bergen Cornelis A M, Szczurek Ewa
Abstract excerpt
Tumours exhibit high genotypic and transcriptional heterogeneity. Both affect cancer progression and treatment, but have been predominantly studied separately in follicular lymphoma. To comprehensively investigate the evolution and genotype-to-phenotype maps in follicular lymphoma, we introduce CaClust, a probabilistic graphical model integrating deep whole exome, single-cell RNA and B-cell receptor sequencing...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.