Article
Genetic subdivisions of follicular lymphoma defined by distinct coding and noncoding mutation patterns.
Blood - 10 Aug 2023
Dreval Kostiantyn, Hilton Laura K, Cruz Manuela, Shaalan Haya, Ben-Neriah Susana, Boyle Merrill, Collinge Brett, Coyle Krysta M, Duns Gerben, Farinha Pedro, Grande Bruno M, Meissner Barbara, Pararajalingam Prasath, Rushton Christopher K, Slack Graham W, Wong Jasper, Mungall Andrew J, Marra Marco A, Connors Joseph M, Steidl Christian, Scott David W, Morin Ryan D
Abstract excerpt
Follicular lymphoma (FL) accounts for ∼20% of all new lymphoma cases. Increases in cytological grade are a feature of the clinical progression of this malignancy, and eventual histologic transformation (HT) to the aggressive diffuse large B-cell lymphoma (DLBCL) occurs in up to 15% of patients. Clinical or genetic features to predict the risk and timing of HT have not been described comprehensively. In this...
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