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Article

Analysis of E2F1 single-nucleotide polymorphisms reveals deleterious non-synonymous substitutions that disrupt E2F1-RB protein interaction in cancer.

International journal of biological macromolecules - 1 Mar 2024

Suleman Muhammad, Khattak Aishma, Akbar Fazal, Rizwan Muhammad, Tayyab Muhammad, Yousaf Muhammad, Khan Abbas, Albekairi Norah A, Agouni Abdelali, Crovella Sergio

Abstract excerpt

Cancer is a medical condition that is caused by the abnormal growth and division of cells, leading to the formation of tumors. The E2F1 and RB pathways are critical in regulating cell cycle, and their dysregulation can contribute to the development of cancer. In this study, we analyzed experimentally reported SNPs in E2F1 and assessed their effects on the binding affinity with RB. Out of 46, nine mutations were...

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Identifiers

PMID: 38242392
DOI: 10.1016/j.ijbiomac.2024.129559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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