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The Number of X Chromosomes Causes Sex Differences in Adiposity in Mice

10 May 2012

Abstract excerpt

Sexual dimorphism in body weight, fat distribution, and metabolic disease has been attributed largely to differential effects of male and female gonadal hormones. Here, we report that the number of X chromosomes within cells also contributes to these sex differences. We employed a unique mouse model, known as the "four core genotypes," to distinguish between effects of gonadal sex (testes or ovaries) and sex...

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Identifiers

PMID: 22589744
DOI: 10.1371/journal.pgen.1002709

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