Article
Single-cell expression quantitative trait loci (eQTL) analysis of SLE-risk loci in lupus patient monocytes.
Arthritis research & therapy - 30 Nov 2021
Ghodke-Puranik Yogita, Jin Zhongbo, Zimmerman Kip D, Ainsworth Hannah C, Fan Wei, Jensen Mark A, Dorschner Jessica M, Vsetecka Danielle M, Amin Shreyasee, Makol Ashima, Ernste Floranne, Osborn Thomas, Moder Kevin, Chowdhary Vaidehi, Langefeld Carl D, Niewold Timothy B
Abstract excerpt
BACKGROUND: We performed expression quantitative trait locus (eQTL) analysis in single classical (CL) and non-classical (NCL) monocytes from patients with systemic lupus erythematosus (SLE) to quantify the impact of well-established genetic risk alleles on transcription at single-cell resolution. METHODS: Single-cell gene expression was quantified using qPCR in purified monocyte subpopulations (CD14++CD16- CL and...
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