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Article

Mouse and Human Monoclonal Antibodies Protect against Infection by Multiple Genotypes of Japanese Encephalitis Virus.

mBio - 27 Feb 2018

Fernandez Estefania, Kose Nurgun, Edeling Melissa A, Adhikari Jagat, Sapparapu Gopal, Lazarte Susana M, Nelson Christopher A, Govero Jennifer, Gross Michael L, Fremont Daved H, Crowe James E, Diamond Michael S

Abstract excerpt

Japanese encephalitis virus (JEV) remains a leading cause of viral encephalitis worldwide. Although JEV-specific antibodies have been described, an assessment of their ability to neutralize multiple genotypes of JEV has been limited. Here, we describe the development of a panel of mouse and human neutralizing monoclonal antibodies (MAbs) that inhibit infection in cell culture of four different JEV genotypes...

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Identifiers

PMID: 29487230
DOI: 10.1128/mBio.00008-18
PMCID: PMC5829823

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