Article
Identification of a Broadly Cross-Reactive Epitope in the Inner Shell of the Norovirus Capsid.
PloS one - 1 Jan 2013
Parra Gabriel I, Azure Jolynn, Fischer Renate, Bok Karin, Sandoval-Jaime Carlos, Sosnovtsev Stanislav V, Sander Peter, Green Kim Y
Abstract excerpt
Noroviruses are major pathogens associated with acute gastroenteritis. They are diverse viruses, with at least six genogroups (GI-GVI) and multiple genotypes defined by differences in the major capsid protein, VP1. This diversity has challenged the development of broadly cross-reactive vaccines as well as efficient detection methods. Here, we report the characterization of a broadly cross-reactive monoclonal...
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