Manipulation of immunodominant variable epitopes of norovirus capsid protein elicited cross-blocking antibodies to different GII.4 variants despite the low potency of the polyclonal sera.

Abstract excerpt

Norovirus is a major cause of viral acute gastroenteritis. The predominant genotype, GII.4, presents a continuous emergence of new variants that could escape immunity developed in previous infections. The emergence of GII.4 variants is associated with multiple mutations on five antigenic sites (A, C, D, E, and G) of the major viral capsid protein. Antigenic site A includes most immunodominant epitopes, while...

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