Article
Immune Checkpoint Inhibitor Therapy and Associations with Clonal Hematopoiesis.
International journal of molecular sciences - 15 Oct 2024
Singh Abhay, Trinchant Nuria Mencia, Mishra Rahul, Arora Kirti, Mehta Smit, Kuzmanovic Teodora, Zokaei Nikoo Maedeh, Singh Inderpreet, Przespolewski Amanda C, Swaminathan Mahesh, Ernstoff Marc S, Dy Grace K, Yan Lunbiao, Sinha Eti, Sharma Shruti, Hassane Duane C, Griffiths Elizabeth A, Wang Eunice, Guzman Monica L, Thota Swapna
Abstract excerpt
Cancer cohorts are now known to be associated with increased rates of clonal hematopoiesis (CH). We sort to characterize the hematopoietic compartment of patients with melanoma and non-small cell lung cancer (NSCLC) given our recent population level analysis reporting evolving rates of secondary leukemias. The advent of immune checkpoint blockade (ICB) has dramatically changed our understanding of cancer biology...
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