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Article

Fitness Landscape of Clonal Hematopoiesis Under Selective Pressure of Immune Checkpoint Blockade

9 Sept 2020

Abstract excerpt

PURPOSE Conventional cytotoxic therapies increase the risk of clonal hematopoiesis and select for TP53-mutant clones, which carry a high risk for transformation to therapy-related myelodysplastic neoplasms. In contrast, the effect of immune checkpoint blockade (ICB) on clonal hematopoiesis is unknown. METHODS Paired peripheral-blood samples taken before and after treatment with ICB were obtained for 91 patients...

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PMID: 33015529
DOI: 10.1200/po.20.00186

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