Infratentorial IDH-mutant astrocytoma is a distinct subtype.

doi:10.1007/s00401-020-02194-y

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Infratentorial IDH-mutant astrocytoma is a distinct subtype.

Acta neuropathologica - 1 Oct 2020

Banan Rouzbeh, Stichel Damian, Bleck Anja, Hong Bujung, Lehmann Ulrich, Suwala Abigail, Reinhardt Annekathrin, Schrimpf Daniel, Buslei Rolf, Stadelmann Christine, Ehlert Karoline, Prinz Marco, Acker Till, Schittenhelm Jens, Kaul David, Schweizer Leonille, Capper David, Harter Patrick N, Etminan Nima, Jones David T W, Pfister Stefan M, Herold-Mende Christel, Wick Wolfgang, Sahm Felix, von Deimling Andreas, Hartmann Christian, Reuss David E

Abstract excerpt

Diffuse IDH-mutant astrocytic tumors are rarely diagnosed in the cerebellum or brainstem. In this multi-institutional study, we characterized a series of primary infratentorial IDH-mutant astrocytic tumors with respect to clinical and molecular parameters. We report that about 80% of IDH mutations in these tumors are of non-IDH1-R132H variants which are rare in supratentorial astrocytomas. Most frequently,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aged

Share to Astrocytoma

Share to Child

Share to Child, Preschool

Share to Infant

Share to Isocitrate Dehydrogenase

Share to Young Adult

Source

Open in PubMed

Identifiers

PMID: 32776277
DOI: 10.1007/s00401-020-02194-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Infratentorial IDH-mutant astrocytoma is a distinct subtype.PMID 32776277Read ↗

IDH-mutant diffuse gliomas: tips and tricks in the era of genomic tumor classification.Semantic proximity Read ↗

IDH-mutant astrocytomas with primitive neuronal component have a distinct methylation profile and a higher risk of leptomeningeal spreadSemantic proximity Read ↗

Dual phenotypes in recurrent astrocytoma, IDH-mutant; coexistence of IDH-mutant and IDH-wildtype components: a case report with genetic and epigenetic analysis.Semantic proximity Read ↗

Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities.Semantic proximity Read ↗

Non-canonical IDH1 and IDH2 mutations: a clonal and relevant event in an Italian cohort of gliomas classified according to the 2016 World Health Organization (WHO) criteria.Semantic proximity Read ↗

Rapid progression to glioblastoma in a subset of IDH-mutated astrocytomas: a genome-wide analysis.Semantic proximity Read ↗

Diffuse Astrocytoma, IDH-Wildtype: A Dissolving Diagnosis.Semantic proximity Read ↗

Molecular Characterization of “True” Low-Grade IDH-Wildtype AstrocytomasSemantic proximity Read ↗

Non-IDH1-R132H IDH1/2 mutations are associated with increased DNA methylation and improved survival in astrocytomas, compared to IDH1-R132H mutations.Semantic proximity Read ↗

Characteristics of IDH-mutant gliomas with non-canonical IDH mutation.Semantic proximity Read ↗

Molecular Characterization of IDH Wild-type Diffuse Astrocytomas: The Potential of cIMPACT-NOW Guidelines.Semantic proximity Read ↗

Canonical amplifications and CDKN2A/B loss refine IDH1/2-mutant astrocytoma prognosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.