Article
Isocitrate dehydrogenase-mutant glioma: Evolving clinical and therapeutic implications.
Cancer - 1 Dec 2017
Miller Julie J, Shih Helen A, Andronesi Ovidiu C, Cahill Daniel P
Abstract excerpt
The metabolic genes isocitrate dehydrogenase 1 (IDH1) and IDH2 are commonly mutated in low-grade glioma and in a subset of glioblastoma. These mutations co-occur with other recurrent molecular alterations, including 1p/19q codeletions and tumor suppressor protein 53 (TP53) and alpha thalassemia/mental retardation (ATRX) mutations, which together help to define a molecular signature that aids in the classification...
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