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Genomic profiles of IDH-mutant gliomas: MYCN-amplified IDH-mutant astrocytoma had the worst prognosis.

Scientific reports - 25 Apr 2023

Lee Kwanghoon, Kim Seong-Ik, Kim Eric Eunshik, Shim Yu-Mi, Won Jae-Kyung, Park Chul-Kee, Choi Seung Hong, Yun Hongseok, Lee Hyunju, Park Sung-Hye

Abstract excerpt

This study aimed to find any ambiguous genetic outlier for "oligodendroglioma, IDH-mutant and 1p/19q-codeleted (O_IDH_mut)" and "astrocytoma, IDH-mutant (A_IDH_mut)" and to redefine the genetic landscape and prognostic factors of IDH-mutant gliomas. Next-generation sequencing (NGS) using a brain tumor-targeted gene panel, methylation profiles, and clinicopathological features were analyzed for O_IDH_mut (n = 74)...

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Identifiers

PMID: 37185778
DOI: 10.1038/s41598-023-32153-y
PMCID: PMC10130138

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